This panel will discuss the future of the anthropological pursuit of understanding of Indigenous Knowledge [Folk wisdom] as it has supported and continues to support using life; and the relevance of this knowledge as nature and populations change in the coming age. The problem of searching for harmony in the Society-Nature relationship continues to be the universal problem for the modern world. Overexploitation of nature and the destruction of original landscapes have brought major problems in ecology, human health and have compelled human activity in searching for a model of sustainable development for mankind. Anthropological science has collected original data about technologies, procedures and cultural traditions, knowledge and tools of using for maintaining life-support activity in the pre-industrial epoch in a regime that required the sparing of nature, as humans did not possess elaborate technologies that permitted them to ignore nature's own requirements. We will focus attention on folk traditions in Nature using and society life (among peoples round the World) that supplement modern knowledge about Nature and society, especially in relation to the increasing demands for multicultural dialog. We will discuss a role of multi-scientific (interdisciplinary) approaches to Indigenous Knowledge research and follow a perspective of involving some Indigenous Knowledge in process of decisions making (for instance in a Green economy and multicultural dialog), directed toward models of Sustainability which will be necessary for society to survive in the 21st century. Cross-cultural investigation in legacies on Indigenous Knowledge will be an immortal problem for the next generation anthropology.